%A M. Weingarten %A Shemin Ge %A Jonathan W. Godt %A B. A. Bekins %A Justin L. Rubinstein %J Science %T High-rate injection is associated with the increase in U.S. mid-continent seismicity %X An unprecedented increase in earthquakes in the U.S. mid-continent began in 2009. Many of these earthquakes have been documented as induced by wastewater injection. We examine the relationship between wastewater injection and U.S. mid-continent seismicity using a newly assembled injection well database for the central and eastern United States. We find that the entire increase in earthquake rate is associated with fluid injection wells. High-rate injection wells (>300,000 barrels per month) are much more likely to be associated with earthquakes than lower-rate wells. At the scale of our study, a well’s cumulative injected volume, monthly wellhead pressure, depth, and proximity to crystalline basement do not strongly correlate with earthquake association. Managing injection rates may be a useful tool to minimize the likelihood of induced earthquakes. %N 6241 %P 1336-1340 %V 348 %D 2015 %I American Association for the Advancement of Science %R doi:10.1126/science.aab1345 %L epos1758